About Nuvastatic
Nuvastatic™ is a scientifically developed botanical formulation made from Lanctos® 75 – a proprietary Orthosiphon stamineus leaf extract standardized to 6% rosmarinic acid.
Backed by over a decade of clinical research, Nuvastatic™ is designed to support patients undergoing cancer treatment by:
-
Reducing cancer-related fatigue
-
Protecting vital organs and tissues against the damaging effects of oxidative stress
-
Supporting healthy immune balance
-
Improving overall well-being and quality of life
Nuvastatic™ is not a replacement for standard cancer therapy. It is used as a supportive or adjuvant botanical under medical supervision.
How Nuvastatic™ Works
Scientific research shows that Nuvastatic™ helps the body through multiple mechanisms:
Antioxidant & Anti-Inflammatory Effects
During chemotherapy or radiation therapy, the body experiences oxidative stress — a buildup of harmful free radicals that damage healthy tissues. The main active compound in Nuvastatic, rosmarinic acid, acts as a potent antioxidant, neutralizing these free radicals and reducing oxidative damage at the cellular level.
Additionally, Nuvastatic helps modulate inflammatory pathways by reducing the activity of key inflammatory mediators such as NF-κB and COX-2, both of which are known to drive chronic inflammation and fatigue during cancer therapy. This dual antioxidant–anti-inflammatory action contributes to reduced treatment-related side effects, improved energy, and enhanced recovery.
2
Anti-Angiogenic Activity
Cancer growth and spread rely on angiogenesis — the formation of new blood vessels that supply nutrients to tumours. Nuvastatic’s active flavonoids and polyphenols, particularly rosmarinic acid, has been shown to inhibit the VEGF (Vascular Endothelial Growth Factor) signalling pathway, which plays a central role in tumour blood vessel formation.
By blocking this pathway, Nuvastatic helps limit tumour vascularisation, reduce oxygen and nutrient delivery to cancer cells, and slow disease progression. This antiangiogenic property supports conventional cancer therapy by targeting one of the key survival mechanisms of tumours — the formation of their own blood supply.
3
Cellular Protection and Mitochondrial Support
Nuvastatic helps maintain the integrity of normal cells during cancer treatment. By stabilizing mitochondrial function, it supports the body’s natural energy production while preventing excessive cell death caused by oxidative and inflammatory stress.
Clinical studies have shown that Nuvastatic can reduce urinary F2-isoprostanes, a biomarker of oxidative damage, indicating its protective effect on the liver, kidneys, and cardiovascular system. These protective actions help preserve organ function, allowing patients to better tolerate ongoing cancer therapy while maintaining quality of life.
Research & Clinical Studies
Nuvastatic™ has been the subject of multiple preclinical and clinical studies conducted by independent investigators and NatureCeuticals’ research research scientists:
-
Cancer-Related Fatigue: Phase II studies show improvement in fatigue and quality of life among cancer patients receiving chemotherapy.
-
Diabetic Retinopathy (Eye Health): Demonstrated reversal of severe non-proliferative diabetic retinopathy, linked to its anti-angiogenic effects.
-
COVID-19 Immunomodulation (Adjunct Study): Improved clinical recovery by reducing inflammation and oxidative stress.
List of Publications:
-
Ng ML, Abdul Majid AMS, Yee SM, et al. A phase II randomized, double-blind, placebo-controlled study of Nuvastatic (C5OSEW5050ESA) to reduce cancer-related fatigue in patients with solid tumors. Support Care Cancer. 2024;32(6):331. doi:10.1007/s00520-024-08536-w. PubMed
-
Yehya AHS, Asif M, Abdul Majid AM, Oon CE. Polymolecular botanical drug of Orthosiphon stamineus extract (C5OSEW5050ESA) as a complementary therapy to overcome gemcitabine resistance in pancreatic cancer cells. J Tradit Complement Med. 2022;13(1):39-50. doi:10.1016/j.jtcme.2022.10.002. (PMCID: PMC9845648). PubMed
-
Al-Suede FSR, Ahamed MBK, Abdul Majid AS, et al. Immunomodulatory and anti-angiogenic mechanisms of polymolecular botanical drug extract C5OSEW5050ESA OS derived from Orthosiphon stamineus. Journal of Angiotherapy. 2021;5(1):194-206. doi:10.25163/angiotherapy.51211411913130321. publishing.emanresearch.org
-
Yehya AHS, Asif M, Abdul Majid AMS, Oon CE. Anti-tumour activity and toxicological studies of Orthosiphon stamineus extract formulation (C5OSEW5050ESA; Nuvastatic™) in vivo. World J Gastroenterol. 2022;28(32):4620-4638. (Article record/abstract available). WJGnet+2The Australian National University+2
-
ClinicalTrials.gov. Evaluation of clinical efficacy and safety of Nuvastatic in cancer-related fatigue in patients with solid tumors (NCT04546607). Registered 2020.
-
Ahamed MBK, Aisha AFA, Nassar ZD, et al. Cat’s whiskers tea (Orthosiphon stamineus) extract inhibits growth of colon tumor in nude mice and angiogenesis in endothelial cells via suppressing VEGFR phosphorylation. Nutrition and Cancer. 2012;64(1):89-99. doi:10.1080/01635581.2012.630160. PubMed+1
-
Dolečková I, Rárová L, Grúz J, et al. Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of Orthosiphon stamineus leaves. Fitoterapia. 2012;83(6):1000-1007. doi:10.1016/j.fitote.2012.06.002. PubMed
-
Al-Suede FSR, Majid ASA, Ismail Z, Kadir MO, Abdul Majid AMS. Marked antitumor activity of Orthosiphon stamineus extract in an orthotopic model of human colon tumor in nude mice. J Biochem Technol. 2012;3(5):S170-S176. (Article/abstract records). jbiochemtech.com+1
-
Al-Suede FSR, Elham F, Ahamed MBK, et al. Optimization of cat’s whiskers tea (Orthosiphon stamineus) using supercritical CO₂ and selective chemotherapeutic potential against prostate cancer cells. Evid Based Complement Alternat Med. 2014;2014:396016. PMC
-
Pauzi N, Mohd KS, Abdul Halim NH, Ismail Z. Orthosiphon stamineus extracts inhibit proliferation and induce apoptosis in uterine fibroid cells. Asian Pac J Cancer Prev. 2018;19(10):2737-2744. doi:10.22034/APJCP.2018.19.10.2737. PubMed+1
-
Al-Suede FSR, Abdul Majid AMS, Ismail Z, Kadir M, Abdul Majid AMS. Antiangiogenic and antimetastatic activities of Orthosiphon stamineus extract against colon cancer cell line (Abstract B87). Cancer Research (AACR Proceedings). 2013;73(3 Suppl):B87. AACR Journals
-
Akowuah GA, Zhari I, Norhayati I, Sadikun A, Khamsah SM. Sinensetin, eupatorin, tetramethoxyflavone and rosmarinic acid contents and antioxidative effect of Orthosiphon stamineus from Malaysia. Food Chem. 2004;87(4):559-566.
Our Products
For Patients
Living with cancer often means coping with fatigue, organ stress, and treatment side effects. Nuvastatic™ is designed to support the body naturally, helping patients maintain strength and quality of life.
How to Access Nuvastatic™:
-
Complete our online patient form.
-
Schedule a tele-consultation with one of our partner oncologists.
-
Receive a personalized care recommendation.
Patients cannot purchase Nuvastatic™ directly. Access is available only through medical screening to ensure safe, appropriate use. Contact us for more information.
For Doctors & Researchers
Get to Know Us
Nuvastatic™ offers a unique botanical approach to cancer support. Its active compounds—particularly rosmarinic acid and flavonoids—demonstrate anti-angiogenic, antioxidant, and immunomodulatory properties.
We invite oncologists, integrative practitioners, and researchers to explore:
-
Mechanism of action data
-
Clinical trial summaries
-
Collaborative opportunities
Medical Practitioners Panel
Our network of experienced medical practitioners provides personalised consultations to determine if Nuvastatic™ is suitable as an adjuvant support for individual patients. Contact us for more information. We will help to link you with the nearest clinic or hospital closest to you.
Oncological Consultation Support
Get in Touch
Natureceuticals Clinical Support
Kuala Lumpur, Malaysia
+60 124 428 007